UNDER- methylation (keeps turning things off) 45% of population  Histadelia

Symptoms of:

  • Seasonal allergies
  • OCD
  • Perfectionism
  • High libido
  • Sparse body hair
  • Blood test indicators
  • High Histamine Levels (blood test would indicate levels – healthy level 40-70 mcg/dL) and absolute basophils (a type of white blood cell involved in immune response)
  • Low levels of serotonin, dopamine, Norepinephrine  (Neurotransmitters)

Food and supplements which help.

  • Omega 3 Oil
  • Calcium
  • Magnesium


  • B-6
  • Folate
  • B-12 (methylcobalamin form - sublingual)
  • Choloine
  • Inositol


  • Methionine
  • Glutathione
  • Taurine


  • Vitamin A, C and E
  • Zinc


  • DMG
  • MSM


  • SAMe

Supplements to avoid

  •  Folic acid

Methionine is an Amino acid derived from proteins.   Your body should be able to convert Methionine along with magnesium into SAMe.

After the delivery of Methyl by the SAMe, it becomes homocysteine. And if homocysteine is then attached to a methyl it turnes back into methionine.

Difficult to follow for me.. What I get of it, is that there is a healthy cycle of methylation.  But deficiencies can disrupt the cycle and that can be a real problem…. It can effect how you handle nutrients, It can raise your homocysteine, which  in excess is a major strain on your overall health.

Bottom line….. Know your levels…. Determine if you are over or under methylation before you start taking supplements.   I am going to put up 2 questionnaires to help determine if you are under or over methylated using symptomology.

This will not replace a blood test but will give a little insight for those who may not have insurance or ability to go to a doctor.

As a base for any health problem, especially in the methylation cycle…Enzymes are critical!!!   I also suggest enteric coated probiotics, a diet rich in organic vegetables/ fruits and healthy fatty acids/ proteins.

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